A compound called creatine is produced in the muscles, and the product formed as a result of the breakdown of this compound is called creatinine.
The level of creatinine in the blood, such as age, gender and muscle mass. may vary depending on certain factors.
The kidneys filter this waste product, which is broken down in the muscles, and remove it from the body with urine. Meanwhile, a balance is formed between production and excretion in the body, and the creatinine level is maintained at the required levels.
If the kidneys do not work properly, the amount in the blood or urine is more than it should be. Bsuch as the way one is being kissed and the person’s physical activity status.A few different conditions can also affect creatinine levels.
Since creatinine levels give very important information about a person’s health, blood or urine tests, kreatinin Controlling the level is very important.
Usually produced by muscles in the bodyrhetin, It can also be produced from amino acids taken with nutrition. Since its production is related to the muscles, creatinine levels are high in people with a high percentage of muscle, while creatinine levels are low in people who are old, weak and have a low percentage of muscle.
known as muscle waste productsrhetin, It can play a role in the fight against diseases by stopping the growth of bacteria in the body.
BLOOD CREATIN TEST
Creatinine levels can be checked from blood tests or urinalysis. The process of measuring the amount of creatinine in the bloodstream, which is measured with the help of blood tests, is called serum creatinine, and the process of measuring creatinine levels in the urine is called creatinine clearance.
Creatinine levels, kby ace levels creatinine levels in women are lower than in men. Creatinine reference range can be between 0.6-1.2mg/dL in men and 0.5-1.1mg/dL in women.
In some cases, it is recommended that the patient perform these tests frequently and have their values checked regularly.
- people with diabetes
- People with high blood pressure
- People with acute kidney injury
- Those with cardiovascular diseases
- Those who have conditions that can adversely affect the kidneys (kidney stones, enlarged prostate, lupus)
- People with a family history of severe hereditary kidney damage
- People who have used or continue to use drugs that adversely affect the kidneys, such as chemotherapy drugs and cephalosporin antibiotics, that tire the kidneys for a long time, should have these tests done regularly at certain intervals.
WHAT LEVEL SHOULD THE CREATINE LEVEL BE?
The units of measure for creatinine levels are known as milligrams per deciliter (mg/dL) or micromoles per liter. The range of creatinine in the blood is specified as 0.84-1.21 milligrams per deciliter (74.3-107 micromoles per liter).
A GFR level of 60 or above is considered normal, while GFR levels below 60 may indicate a disease in the kidneys. A GFR of 15 or less is defined as kidney failure. The creatinine dialysis limit is considered to be 0.1-0.15 ml/minute/kg (7-11 ml/minute in a 70 kg patient).
HEIGHT OF CREATIN
It is understood that when creatinine levels in the blood rise, creatinine production in the muscles or any other part of the body increases. Among the factors that can cause an increase in creatinine in the blood;
Chronic kidney disease, urinary tract obstruction, dehydration, excessive protein consumption, intense exercise, certain medications, certain autoimmune diseases (For example Lupus), goodpasture syndrome, gout, rhabdomyolysis (breakdown of muscle fibers), muscular dystrophy, injury Problems such as blood loss, overactive thyroid gland, congestive heart failure, diabetes, seizures caused by eclampsia in pregnancy or high blood pressure caused by preeclampsia, glomerulonephritis, which is inflammation of the glomerulus, can be counted.
High levels of creatinine in the blood indicate that there is a problem in the functioning of the kidneys and that the creatinine formed in the body cannot be properly filtered and excreted by the kidneys.
SYMPTOMS OF HIGH CREATIN
- Nausea in stomach
- Fatigue, weakness
- Loss of appetite and associated weight loss
- frequent urination,
- painful-bloody urine
- high blood pressure levels
- Chest pain,
- muscle cramps
- Trouble in breathing
- Dryness of the skin
Lower than normal creatinine levels may indicate that the liver or muscles are not working as they should.
WHY IS CREATIN DOWN?
Low Muscle Mass: Age, gender, some diseases may play a role among the causes of low muscle mass. Examples of these diseases are myasthenia gravis, muscular dystrophy. Excessive weight loss also causes muscle levels to drop.
Pregnancy: Low creatinine may occur as a result of increased urine production and increased water loss during pregnancy, but this situation ends with the termination of pregnancy.
Liver Problems: Due to the fact that creatine is produced in the liver, low creatinine levels can be seen with the impairment of liver functions because creatinine cannot be produced at normal levels. In chronic liver disease, creatine production may decrease by 50%.
Malnutrition: It is known that creatine is produced in the body as well as taken from food, so nutrition is very important.
SYMPTOMS OF LOW CREATIN
If the underlying cause of low creatinine is liver disease, symptoms include fatigue, nausea, jaundice, abdominal pain, swelling, bloody or tar-colored stools.
If the underlying cause is nutritional problems, symptoms such as dizziness and weight loss are observed. Other known symptoms are as follows:
- Weakness in the muscles
- Exercise difficulty
- Muscle pain and decreased mobility
TREATMENT OF LOW CREATIN
When test results show low creatinine levels, other tests are done to prevent certain muscle diseases. Muscle biopsy or muscle enzyme test is performed to see the extent of muscle damage.
To treat this condition, it is necessary to know the underlying factor that causes low creatinine.